@article{oai:swu.repo.nii.ac.jp:00000386,
 author = {海老沢, 秀道 and 岩谷, 美咲 and 鬼窪, 麻衣 and 瀧山, 花穂 and 竹本, 歩実 and 松本, 美寿穂 and 清水, 史子 and EBISAWA, Hidemichi and IWATANI, Misaki and ONIKUBO, Mai and TAKIYAMA, Kaho and TAKEMOTO, Ayumi and MATSUMOTO, Mizuho and SHIMIZU, Fumiko},
 issue = {914},
 journal = {学苑, Gakuen},
 month = {Dec},
 note = {The present study was carried out to elucidate the protective effects of dietary L-arginine and soy isoflavone-extracted on the bone metabolism in the ovariectomized chronic kidney disease model rats.
　　Nine-week-old female rats received 360mg/kg BW of adenine intragastrally for four consecutive days so that they would develop chronic kidney disease（CKD）. After six days of recovery, rats received ovariectomies（OVX）under anesthesia. A sham operation was carried out on another group of rats（group Intact）.
　　Seven days after the OVX, the rats were given either a control diet（20％ casein protein diet（group CA）; 0.5％ L-arginine supplemented diet（group Arg）; or 0.20％ soy isoflavone-extracted supplemented diet（group IF）, 13g per day for 12 weeks. Rats in group Intact were, like group CA, given the control diet.
　　The results were as follows: 
1）Group CA developed moderate chronic kidney disease which was manifested as elevated kidney weight, increased serum creatinine, relatively lower creatinine clearance and reduced femoral-BMD than that of group Intact.
2）The L-Arginine supplemented diet did not improve renal function and femoral BMD-loss. But, increased mRNA expression levels of IGF-1, BMP-2 and Osterix were observed in the femurs.
3）Soy isoflavone-extracted supplemented diet had no preventative effects on BMD loss, although estrogen receptor-beta mRNA expression levels in the femurs were elevated.
　　From these results, bone-protective functions of L-arginine via activation of osteoblast differentiation and bone formation process were suggested. Further investigation to clarify the efficacy of L-arginine-IGF-1 signal transduction on the bone metabolism is required to determine whether a therapy based on this approach can help people suffering from osteoporosis in CKD patients.},
 pages = {６--14},
 title = {〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究},
 year = {2016},
 yomi = {エビサワ, ヒデミチ and イワタニ, ミサキ and オニクボ, マイ and タキヤマ, カホ and タケモト, アユミ and マツモト, ミズホ and シミズ, フミコ}
}