{"created":"2023-05-15T11:49:35.541260+00:00","id":386,"links":{},"metadata":{"_buckets":{"deposit":"a31fdc7d-1dc9-4b45-8a33-c90d2a908399"},"_deposit":{"created_by":22,"id":"386","owners":[22],"pid":{"revision_id":0,"type":"depid","value":"386"},"status":"published"},"_oai":{"id":"oai:swu.repo.nii.ac.jp:00000386","sets":["107:282:106"]},"author_link":["889","890","887","880","881","893","883","892","886","888","891","884","885","882"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"914","bibliographicPageEnd":"14","bibliographicPageStart":"６","bibliographic_titles":[{"bibliographic_title":"学苑"},{"bibliographic_title":"Gakuen","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study was carried out to elucidate the protective effects of dietary L-arginine and soy isoflavone-extracted on the bone metabolism in the ovariectomized chronic kidney disease model rats.\n　　Nine-week-old female rats received 360mg/kg BW of adenine intragastrally for four consecutive days so that they would develop chronic kidney disease（CKD）. After six days of recovery, rats received ovariectomies（OVX）under anesthesia. A sham operation was carried out on another group of rats（group Intact）.\n　　Seven days after the OVX, the rats were given either a control diet（20％ casein protein diet（group CA）; 0.5％ L-arginine supplemented diet（group Arg）; or 0.20％ soy isoflavone-extracted supplemented diet（group IF）, 13g per day for 12 weeks. Rats in group Intact were, like group CA, given the control diet.\n　　The results were as follows: \n1）Group CA developed moderate chronic kidney disease which was manifested as elevated kidney weight, increased serum creatinine, relatively lower creatinine clearance and reduced femoral-BMD than that of group Intact.\n2）The L-Arginine supplemented diet did not improve renal function and femoral BMD-loss. But, increased mRNA expression levels of IGF-1, BMP-2 and Osterix were observed in the femurs.\n3）Soy isoflavone-extracted supplemented diet had no preventative effects on BMD loss, although estrogen receptor-beta mRNA expression levels in the femurs were elevated.\n　　From these results, bone-protective functions of L-arginine via activation of osteoblast differentiation and bone formation process were suggested. Further investigation to clarify the efficacy of L-arginine-IGF-1 signal transduction on the bone metabolism is required to determine whether a therapy based on this approach can help people suffering from osteoporosis in CKD patients.\n","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"昭和女子大学近代文化研究所"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-0103","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"海老沢, 秀道"},{"creatorName":"エビサワ, ヒデミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩谷, 美咲"},{"creatorName":"イワタニ, ミサキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鬼窪, 麻衣"},{"creatorName":"オニクボ, マイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"瀧山, 花穂"},{"creatorName":"タキヤマ, カホ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹本, 歩実"},{"creatorName":"タケモト, アユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 美寿穂"},{"creatorName":"マツモト, ミズホ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 史子"},{"creatorName":"シミズ, フミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"EBISAWA, Hidemichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWATANI, Misaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ONIKUBO, Mai","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKIYAMA, Kaho","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKEMOTO, Ayumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUMOTO, Mizuho","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Fumiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-12-20"}],"displaytype":"detail","filename":"02学苑12月海老沢先生他.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"02学苑12月海老沢先生他","url":"https://swu.repo.nii.ac.jp/record/386/files/02学苑12月海老沢先生他.pdf"},"version_id":"45884ebb-8555-4614-9c03-099733e6a8c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性腎臓病モデルラット","subitem_subject_scheme":"Other"},{"subitem_subject":"アルギニン","subitem_subject_scheme":"Other"},{"subitem_subject":"大豆イソフラボン抽出物","subitem_subject_scheme":"Other"},{"subitem_subject":"BMD","subitem_subject_scheme":"Other"},{"subitem_subject":"骨密度","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney disease model rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"L-Arginine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"soy isoflavone-extract","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BMD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteroporosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究"},{"subitem_title":"A Basic Study of the Efficacy of the Dietary L-Arginine and Soy Isoflavone-Extracted on the Bone Metabolism in Ovariectomized Chronic Kidney Disease（CKD）Model Rats","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"22","path":["106"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-20"},"publish_date":"2016-12-20","publish_status":"0","recid":"386","relation_version_is_last":true,"title":["〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究"],"weko_creator_id":"22","weko_shared_id":-1},"updated":"2023-05-15T14:09:03.278981+00:00"}