{"created":"2023-05-15T11:53:51.464276+00:00","id":5542,"links":{},"metadata":{"_buckets":{"deposit":"93646021-1470-4bec-b162-b8593a94ba11"},"_deposit":{"created_by":4,"id":"5542","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"5542"},"status":"published"},"_oai":{"id":"oai:swu.repo.nii.ac.jp:00005542","sets":["107:282:469"]},"author_link":["9167","9166","9170","9173","9168","9171","9172","9169"],"item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"55","bibliographicPageStart":"47","bibliographicVolumeNumber":"866","bibliographic_titles":[{"bibliographic_title":"學苑"},{"bibliographic_title":"GAKUEN","bibliographic_titleLang":"en"}]}]},"item_3_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":" The present study was carried out to determine whether dietary isoflavone and arginine could preserve the renal function and prevent renal injury and bone mineral density loss in the chronic kidney disease model rat. We orally administered 360mg/kg BW of adenine suspended in methylcellulose to ten-week-old male Wistar rats for six days to generate a chronic kidney disease(CKD)model. As a control, methylcellulose alone was administered to another group of rats(Intact). The rats received 15g/day of either the control diet(group CA)or the experimental diet supplemented with isoflavone(group IF)or L-Arginine(group Arg)or isoflavone plus L-Arginine simultaneously(group IFA)for 10 weeks. Group CA still showed the symptoms of chronic kidney disease, such as renal swelling, a decreased CCr, elevated BUN and increased urinary NAG activity compared to the Intact rats that had not received adenine treatment. The results were as follows: Compared with group CA, 1)Group IF showed a higher femoral cancellous-BMD, but no improvement in the renal function estimated by the CCr and BUN or the renal injury levels estimated by the urinary protein excretion and urinary NAG activity. 2)Group Arg showed a higher CCr, lower BUN and lower urinary protein excretion; however, the femoral cancellous-BMD did not increase. 3)Group IFA showed a lower urinary protein excretion level and urinary NAG activity and higher femoral cancellous-BMD. These results suggest that isoflavone and arginine are effective dietary agents for suppressing renal failure and maintaining the BMD in a rat model of chronic kidney disease.","subitem_description_type":"Other"}]},"item_3_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"9","subitem_description_type":"Other"}]},"item_3_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00008164300","subitem_description_type":"Other"}]},"item_3_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00038441","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13480103","subitem_source_identifier_type":"ISSN"}]},"item_3_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"昭和女子大学大学院生活機構研究科生活科学研究専攻生"},{"subitem_text_value":"昭和女子大学健康デザイン学科"},{"subitem_text_value":"東京医科歯科大学大学院 医歯学総合研究科"},{"subitem_text_value":"昭和女子大学管理栄養学科"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"間野, 琴子"},{"creatorName":"マノ, コトコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮内, 智美"},{"creatorName":"ミヤウチ, トモミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"春宮, 覚"},{"creatorName":"ハルミヤ, サトル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"海老沢, 秀道"},{"creatorName":"エビサワ, ヒデミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kotoko, MANO","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomomi, MIYAUCHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoru, HARUMIYA","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidemichi, EBISAWA","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"KJ00008164300.pdf","filesize":[{"value":"916.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00008164300.pdf","url":"https://swu.repo.nii.ac.jp/record/5542/files/KJ00008164300.pdf"},"version_id":"4585b07d-524a-4761-af52-f9697244a1dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性腎臓病モデルラット,イソフラボン抽出物,アルギニン,腎機能,骨密度","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney disease model rat,isoflavone extracted,L-Arginine,renal function,bone mineral density","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〔研究ノート〕慢性腎臓病モデルラットの骨密度維持に対する食餌アルギニンあるいは大豆イソフラボン抽出物投与の有効性評価に関する基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〔研究ノート〕慢性腎臓病モデルラットの骨密度維持に対する食餌アルギニンあるいは大豆イソフラボン抽出物投与の有効性評価に関する基礎的研究"},{"subitem_title":"A Basic Study of the Efficacy Assessments of the Dietary L-Arginine and Soy Isoflavone Extracted on the Maintenance of Bone Mineral Density in Chronic Kidney Disease(CKD)Model Rats","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["469"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-16"},"publish_date":"2017-02-16","publish_status":"0","recid":"5542","relation_version_is_last":true,"title":["〔研究ノート〕慢性腎臓病モデルラットの骨密度維持に対する食餌アルギニンあるいは大豆イソフラボン抽出物投与の有効性評価に関する基礎的研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-05-15T14:04:11.991261+00:00"}