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〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究
https://swu.repo.nii.ac.jp/records/386
https://swu.repo.nii.ac.jp/records/3860b813810-6baa-4023-a7f6-1dd1cef06959
名前 / ファイル | ライセンス | アクション |
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02学苑12月海老沢先生他 (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-12-20 | |||||
タイトル | ||||||
タイトル | 〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A Basic Study of the Efficacy of the Dietary L-Arginine and Soy Isoflavone-Extracted on the Bone Metabolism in Ovariectomized Chronic Kidney Disease(CKD)Model Rats | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 慢性腎臓病モデルラット | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アルギニン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大豆イソフラボン抽出物 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BMD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨密度 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨粗鬆症 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chronic kidney disease model rat | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | L-Arginine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | soy isoflavone-extract | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | BMD | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | osteroporosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
海老沢, 秀道
× 海老沢, 秀道× 岩谷, 美咲× 鬼窪, 麻衣× 瀧山, 花穂× 竹本, 歩実× 松本, 美寿穂× 清水, 史子× EBISAWA, Hidemichi× IWATANI, Misaki× ONIKUBO, Mai× TAKIYAMA, Kaho× TAKEMOTO, Ayumi× MATSUMOTO, Mizuho× SHIMIZU, Fumiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study was carried out to elucidate the protective effects of dietary L-arginine and soy isoflavone-extracted on the bone metabolism in the ovariectomized chronic kidney disease model rats. Nine-week-old female rats received 360mg/kg BW of adenine intragastrally for four consecutive days so that they would develop chronic kidney disease(CKD). After six days of recovery, rats received ovariectomies(OVX)under anesthesia. A sham operation was carried out on another group of rats(group Intact). Seven days after the OVX, the rats were given either a control diet(20% casein protein diet(group CA); 0.5% L-arginine supplemented diet(group Arg); or 0.20% soy isoflavone-extracted supplemented diet(group IF), 13g per day for 12 weeks. Rats in group Intact were, like group CA, given the control diet. The results were as follows: 1)Group CA developed moderate chronic kidney disease which was manifested as elevated kidney weight, increased serum creatinine, relatively lower creatinine clearance and reduced femoral-BMD than that of group Intact. 2)The L-Arginine supplemented diet did not improve renal function and femoral BMD-loss. But, increased mRNA expression levels of IGF-1, BMP-2 and Osterix were observed in the femurs. 3)Soy isoflavone-extracted supplemented diet had no preventative effects on BMD loss, although estrogen receptor-beta mRNA expression levels in the femurs were elevated. From these results, bone-protective functions of L-arginine via activation of osteoblast differentiation and bone formation process were suggested. Further investigation to clarify the efficacy of L-arginine-IGF-1 signal transduction on the bone metabolism is required to determine whether a therapy based on this approach can help people suffering from osteoporosis in CKD patients. |
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書誌情報 |
学苑 en : Gakuen 号 914, p. 6-14, 発行日 2016-12-01 |
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出版者 | ||||||
出版者 | 昭和女子大学近代文化研究所 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1348-0103 |